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Biochemical dysphoria refers to a state of emotional or mental discomfort that is believed to be influenced by imbalances or disruptions in the biochemical processes of the body, particularly those related to neurotransmitters and hormones - Ref. NAWHEHAPFD.
For cisgender individuals, many hormonal imbalances have been shown to cause depression, anxiety or other mood related difficulties - Ref. JHUQAJPIVG. Where transgender people are concerned, the precise nature of what constitutes an “imbalance” is a nuanced topic and something which remains to be decided by the scientific community - potentially, in part because the precise mechanism behind the development of gender dysphoria is not yet clear.
Nonetheless, plenty of research suggests that hormone replacement therapies drastically improve the mental state of many transgender patients - alleviating anxiety, depression and low mood. Ref. KKQYHSULQL
“Biochemical Gender Dysphoria” may be used to describe the feeling of unease that a transgender person experiences when their hormone profile does not align with that of their gender.
Biochemical Dysphoria & Variability
Given the complexity of chemical interactions in the human body, a person’s triggers may involve a shifting combination of internal and external factors. Some biochemical responses are influenced by environmental stimuli, meaning outside forces can also play a role. Ref. 191W6XOM6N
Some variables which may negatively impact biochemical dysphoria:
For Transfeminine People People assigned male at birth may experience fluctuations in testosterone caused by attraction, desire, arousal - Ref. ADNSKBSQ8Z and waking up at the start of their day. Ref. TAGF3PTKPH
For Transmasculine People People assigned female at birth may experience fluctuations in oestrogen and progesterone, affected by the menstrual cycle or pregnancy. Ref. WCKWJOOULA
Studies show that emotional dysregulation is closely linked to worsening mental health outcomes. As such, other factors that negatively affect mood may also exacerbate dysphoria.
- Low blood sugar has been shown to intensify feelings of anxiety and fear. Ref. MMJUP569XE
- Substance withdrawal is associated with extreme distress and heightened emotional reactivity. Ref. 1KMJ7F6GJ7
- Hypothyroidism can make a person feel depressed or apathetic. Ref. KSFKF4B2G0
These are just a few examples of many conditions known to affect a person’s mood.
In short: Variations in neuroendocrine activity, hormone levels, and other physiological factors may contribute to changes in the intensity of dysphoric sensations. These may range from stable, persistent states to fluctuating experiences that shift over minutes, days, or longer periods.
Managing Biochemical Gender Dysphoria
Studies indicate that Hormone Replacement Therapy is an excellent tool in treating biochemical dysphoria. Despite this, it’s worth pointing out that such treatment is not accessible, nor viable to everyone.
Even without hormone therapy, things which can promote general good health and a good mood could be an excellent way to lessen the impact of biochemical dysphoria.
What is effective is deeply personal, so experimentation is key.
Activities that help distract from body-related sensations can be a good starting point. This might include playing video games to “switch off” or doing sports that don’t focus heavily on the body. However, some physical activities can heighten body awareness and increase discomfort for transgender people, so it’s important to find what works best for each individual.
Some Suggestions
- Healthy activities like sports or hobbies.
- Eating well and drinking plenty of water.
- Meditation and / or grounding breath exercises.
- Using a Sensory Toolkit.
- Talk therapies / Counselling
If you have concerns about your health and well-being, it is important to consult with a licensed medical professional.